As Napoli has continued to perform well in the Champions League and Serie A, they look unlikely to make any mistakes against Sassuolo. Sassuolo is not a very strong team. But the important thing is that Sassuolo's defense is strong enough. So if Napoli's attack is not able to play well, I think the match is likely to be a draw. But I feel the match will not be one-sided. We will get a chance to watch a competitive match.
My prediction this time is Napoli will win narrowly at home to Sassuolo, even though the match between the two of them had experienced a draw when Napoli played at home to Sassuolo. But this time I'm more sure that Napoli will win again even if not by a lot of scores. Because Napoli have never lost in Serie A, Napoli will definitely try their best not to lose and on the other hand Napoli also want full points in the match with Sassuolo.
I don't see Sassuolo's defense as strong, but maybe not to say it's working badly. One of Napoli's strengths this season is that their attacking line has worked very well and as evidenced by the 26 goals they scored, they are the most fertile team in Serie A. In this way, Napoli have the capital they expect to penetrate the defense built by Sassuolo with ease. They have found good chemistry in attack, now it's just a matter of how they will use it.