As hardware you need a decent device that you can leave running for long time, preferably 24/7, but not necessarily, since after the initial (long) blocks' download, afterwards it would be rather quick (of course, it depends on how many hours or days you don't sync). What is important is to have a big disk (preferably more than 1TB) also if you don't have too much patience then SSD would be better.
There is however, this topic you may want to read (Cheap Node Self Hosting: Just because you CAN does not mean you SHOULD) telling about the hardware choices. The worse the hardware, the more time you'll waste. So you better use decent hardware.

Knowledge: it depends on what you want. Starting Bitcoin core alone is not difficult. Configuring it is not difficult either. If you want more (eg. I have Bitcoin Core, and Electrum Server so I can use my hardware wallet with Electrum and also I have a block explorer), you need at least patience and some basic skills in following instructions on installing this or that (usually under Linux), but if you're not too picky there are tutorials too.

I'll get back to te system. While most of the things are made for Linux, nowadays you can put a Linux subsystem under your Windows 10 or 11. So you don't have to worry much.

----
All in all, I think that running your own node is not that difficult. And if one just wants to avoid the FTX like problems, he doesn't necessarily need a node; just get a hardware wallet and use it with Electrum and you're already way better than most.