Over for crypto, no ways that's far from it! Binance isnt the first exchange to be in the big boys league and if they ever get into that entanglement its most likely another exchange will take its place and crypto living moves on...and the crypto way of doing business will get more smarter and better.

Crypto was doing fine just before the centralized exchanges came and it will continue to live on if a Cex like Binance goes down,only problem with this is many users will be affected as they might be holding coins on the exchange which means markets will bleed for some time.

Can we do without them? Let's just say we have become comfortable with a Cex and at this point cannot do without them.