Holding that amount of bitcoins on an exchange is absolutely insane to begin with. It's surprising how many people are not perturbed by the risks and disadvantages of keeping funds in the control of a third party.
As depositors take larger steps to protect their wealth and secure holdings, will it be enough to stem a tide of the high number of electronic hacks we've witnessed in 2022?
Exchanges would continue to operate as there are still lots of users who entrust them with their funds and trade on their platforms, and ifbhey keep running, there would always be hackers trying to get in. How successful they would be would depend on how much security measures exchanges adopt in the wake of the hack waves.
It seems that the latest trend of large withdrawals came about in 2017. Perhaps after the bitfinex and tether investigations were launched. It could take time for consumer confidence to be restored in crypto exchanges.
Hopefully the confidence is never restored.