The interesting thing, as someone who disliked Trump all his presidency, he sucks and he is bad and I still dislike him but I also come to realization that there aren't any "huge" differences with others neither.
And that is a trouble, if you look at who could be the candidates from the republican side, they all suck, still most have a better face for it, like they are kinder when they talk usually but then go about and do the same thing, so the end result is always the same, and for democrats Biden is kinder and nicer person but then goes and does the same thing mostly. Which means, Trump or someone else, we will have people who will do the same thing, but be nicer about it, and be kinder to people while doing it, not much change in the end result though.
One thing Trump could do that others wouldn't is to quit ties with NATO. As he alreasy haa threaten to do so. This could lead to full blown war with Europe and Russia that would spread like a wild fire towards ww3. I am not even kidding, i know people like to use ww3 as a cliche scare tactic, but this war would in a whole different scale, like something we haven't ever seen before.
I am not sure if his voters care as lot's of them wouldn't understand that it would very much affect them.
However i can't see this affecting betting ratios.