If you send any coins to the public key used in Genesis blocks, the coins may never move but they are not lost because Satoshi created that key and may have the private key still stored somewhere so that he can spend those coins in the future if he chooses to.
The genesis block coins can never be spent:
https://coingeek.com/the-mystery-of-the-genesis-block/The 50
BTC block reward from block #0 or Genesis block is the only
output (UTXO) that can not be spent. Anything else you send to the public key (or the corresponding address) is a
new UTXO that is like any other coin on the blockchain and can be spent the same way.