I just found out that even if you open 100 ETH addresses using Metamask, once your key is been compromised all the 100 ETH addresses are gone, but in case of Trust wallet each addresses has different recovery seed ..
If you are talking about a private key, I do not think it will affect other addresses on the metamask if ever it got compromised. I think it is the seed phrases that will affect all the address in the metamask if it is compromised. Seed phrase is the door to all your eth address, it is the master key to all your addresses.
If you don't know this before you should know now, please take note, some people are using Metamask multiple wallet addresses and they don't understand the risk involved.
You can use Metamask and create a different account with different seed phrases to create unrelated wallet addresseses. Just import them to the Metamask if you wanted to have access to each address created by different seed phrases.