Much will depend on what lineup Juventus can play in this confrontation - if the series of injuries to the main players continues, then obviously Juventus' affairs in Serie A will be shaky. In this case, they will easily sacrifice the Europa League and focus all their energy on Serie A. Therefore, it could turn out to be an easy walk for Nantes (which no one expects now).
Fortunately, at the moment their players are quite good and it is hoped that it will continue like that, especially if you look at the current date, the play-offs will take place in one month because it will be held in February, so they must try to maintain the fitness of the players.
But with the current conditions and seeing how messy Union is at the moment I think they have a very big chance to be in the Europa League.