The meeting between Juventus vs Nantes will be their first meeting, I don't remember whether they have met in a match or not. On paper, who wouldn't make Juventus a clear favorite who clearly has very good strength compared to their current opponents.
There is no need to overemphasize this match; it is clear that Juventus has a better chance of winning. Nantes has struggled in their domestic league, which cannot be compared to Juventus' performance in Serie A. They've lost six matches, drawn eight, and won only three of the 17 matches they've played so far, placing them 15th in the standings. Although they have struggled in their domestic league, we don't know if they will put in more effort in the Europa League to advance to the next round of the competition.