Only inside a Windows VM or maybe using Wine. But I don't see why anyone would want to do that, since there are macOS build binaries available.

Regarding speed: I've ran Compac F's from cgminer in a VM (I like to use VMs when experimenting with a codebase to get an understanding of it & that prevents clutter on my host when installing different compilers, dependencies and whatnot) and it was fine.

USB passthrough has come a long way!