Use a Linux system, but you will have to install the applications yourself from the package manager, and only use portable apps if you verified the release or trust the vendor.
The chances of stock malware breaking into an X Windows desktop on Linux is nil, because they're all written for Windows. You would have to be specifically targeted like Dashjr was in order to be at risk.
But whatever you do, do not install WINE with Electrum, or at the very least, disable or uninstall WINE, as it enables running Windows programs on Linux including malware. Not that many hackers are aware of that, but still.
Thanks for the tips. I'll make sure to remember this.
As one of the security measures, you truly need to learn Linux if you are involved in cryptocurrencies. It's not that hard. But if you truly need to run Windows, you can run it as a VM within your Linux OS. It's much safer.
I would never use Windows + Chrome/Firefox for my exchange/banking/Bitcoin needs, it's just a security hole, and a hack/malware waiting to happen. Plus you said you use Windows' Defender. I hope you don't watch porn in that PC.