I'm now believing in Manchester United they may succeed in defeating Barcelona. If Manchester United was able to defeat Manchester City in the premier league I don't see Barcelona to be that difficult for them. Manchester United is good to challenge any big team.
Maybe yes, maybe no.
Manchester City previously was lost to Southampton too, so we can say Manchester City performance doesn't really good recently. While Barcelona they have beat Real Madrid which is previous winner of Champions League, you need to know if Champions League is higher than Europa League.
I still think Barcelona has a slight advantage maybe 55-60% to win against Manchester United that either 40-45% to win.
After the break Manchester City is having form issue just because of this now they are losing points in Premier League, but Barcelona is surely having different way like they play in yesterday game against Real Madrid things looking amazing, and we can expect good fight for the next round between these two clubs with most chances both are having equal chance for qualifying into next round because now things looking positive and they both have enough quality and match winners.
Now how they respond on match day this could be completely different story with win against Manchester City their confidence level is high, and they can beat any team because this is the biggest win under Ten Hag era for them, and they are completely different team with this all.