Indeed, in the match later, one thing that is most feared is if there are major players who suffer injuries during matches in their respective regular leagues. But talking about injuries, sometimes there are some players who get injured during training sessions and that is also something that coaches should be aware of. However, if Man United vs Barcelona later appears with the full main squad, it seems that the match will run more exciting and it will be even more difficult to guess who will win.
As far as I know, the teams don't have big losses of players, so for now the coaches shouldn't worry about it. Yesterday's game showed that Manchester United did not have a big advantage against Crystal Palace, and this is not the strongest team in the Premier League. The first game of the teams will be played at the Camp Nou, and if you look at the statistics, then Barcelona this season at home lost only to Bayern, so the chances of Manchester United will not be so great.