PvP gambling would be awesome. Many years ago there was a platform that let you gamble against other players in an online mini putt putt game. It was fun. This was pre-crypto. The problem is that people always find a way to cheat or they master certain things so it isnt as fair as it should be. One day gambling will find its way into popular video game systems though. When you can bet real money against players on your Xbox playing popular games, that will be awesome.
I think as long as it involves skills people will try cheating.