No one that can help with this issue?
Antivirus, windows defender?
I excluded my entire miner programs folder in windows defender. All other miners are working,T-Rex is the last one i didnt get back up and running after moving to windows 10.
I take it you have downloaded the latest t-rex from the link on the first page and your drivers are uptodate.
Regretfully I cannot help you any further with Windows as I am running Debian testing as my daily driver and on another rig for mining.