Profitability will depend on what type of service you provide. If you are an e-commerce business, such as selling educational materials or any trading signals, then the volatility of bitcoin should not affect you in any way. After all, you have not spent anything material and all your resource costs are your time and energy. If you were selling someone else's goods for which you had to shell out N-th amount of money, and then selling it for btc, then volatility can play a cruel trick on you here. But even here, it is possible to outwit this bitcoin's feature. Always keep a cash in reserve, with which you will buy goods that you will sell for a btc. As a result, spend cash and accumulate bitcoin until selling btc becomes profitable.

P.S. Don't take my advice as the recommendation of an experienced businessman. These are just hypothetical thoughts of the deliant.