One of the main difficulties encountered with creating an NFT collection is the lack of knowledge about blockchain technology and cryptocurrency. Additionally, creating digital assets from scratch can be a time-consuming process, especially when it comes to selecting and designing artwork for your tokens. Furthermore, setting up a secure wallet for asset storage, as well as dealing with unfamiliar terms such as 'gas fees', can also present challenges. That being said, once you understand the steps required to create an NFT collection, the process becomes much easier.