I don't think so, even though in the end Dembele was absent but there are still some players like Raphinha who will indeed be able to fill that position. On the other hand, when looking at some of Barelona's current matches, Xavi always makes some unique attempts, the results are very good, one of which is saving Gavi as a winger, not as an attacking midfielder, and I think this is still worth it.
As for Casimero he received a red card in the EPL and this has nothing to do with the playoffs now, it's just that Manchester United still have several players in doubt due to fitness problems there.
The absence of Dembele would be replaced by Raphina while the loss of Busquet would be replaced by Kessie who was part of the last game at home for Barcelona against Sevilla.
The red card to Casemiro will not affect him being present in the game and not also during the EFL Cup. Ever since he touch down and signed for Man United he has being one of the best player's and having him absence will be obvious in the squad.
Both Gavi and Pedri are young brilliant players representing the club very well. It looks like Barcelona will win because United gets it difficult to win Some clubs in Spain last year
At the moment for Barcelona it will still be very good but for Manchester United it is clear that there are some things that need to be fixed now.
The absence of several players such as Martial, Eriksen and several others who are still unable to play is clearly a disadvantage now.
The presence of Weghorst in Manchester United's attack has not made a significant impact at this time.
It's just that some of the young players who played like Pedri or Gavi at Barcelona and of course Rashford and Garnacho at Manchester United make me curious now.