It depends on what you need it for.
For small purchases on Amazon etc., you can buy gift cards and vouchers. Or just stay below your CGT threshold.
If you need to sell a large amount, e.g. to buy a house, selling BTC for a truckload of suitcases filled with cash may be tricky. And even if you do, the taxman may one day ask you where you got the money from to buy the house with.
In some countries there is no CGT on crypto gains. In Europe, I reckon Portugal is one of those. If you want to cash out a large amount, obtaining a tax residency in such a country, then selling your BTC for euros (or real estate) might be an attractive option, but it's better to consult a tax advisor to make sure everything is above board.