Manchester United has lost only one game out of eleven home games so far. Since Barcelona has to win it it's either through luck in a penalty shootout or they need a pretty good day to take this away from United.
Nantes vs. Juventus will be rough for Juventus I think. Nantes must be unbelievably motivated to brighten the final result of their season. If they make it against Juventus it is already a huge success for them. They are also still in the Coup de France and they are relatively safe from relegation in Ligue 1. The draw in Italy is now one big step to a great success story for them. I expect a strong fight from them.
Winning against all those other teams are understandable, winning against Barcelona is different. I am not saying United will lose or anything like that, they could still end up being the winners, but at the same time I am saying that this will be harder than almost all of those home games, because they are facing a team that by all accounts should have been in UCL and not europa, they are a very good team.
United of course got better as well and they are very good but that doesn't change the fact that both teams will face very tough opponents and we have no idea how it will end. I still root for Barcelona obviously, but have to say it's equal powers fighting.
Manchester is prepared and can be able to win any team they face with the great form of Bruno and Rashford. Also having Casemiro in the midfield is a great boast to Manchester United squad. In the other hand Barcelona has skillful players that can be able to open any defence but Manchester United David De Gea is a top notch.