I'd consider COVID related matters to be the biggest driver of bankruptcy within the last two years. Interest rates, inflation, labor shortages are all a result of COVID lockdowns causing the government to begin printing money as a form of economic stimulation. All the meanwhile, businesses are forced to close down.

To the extent government can force you to close your business, I don't know what an entrepreneur is suppose to do to combat that. Being flexible with e-commerce might be a mitigating factor but that isn't feasible for a lot of businesses.