Statistically wise, Donaire has all the advantages over Santiago.

Some of these are height advantage, reach advantage, better KO percentage, much faster, much quicker, having a strong punch, good at counter-attack, versatile, agile, better footwork, and what else, much good looking, just kidding.

Santiago should not be a problem for a 40-year-old Donaire since Moloney, the supposed original match is even considered much tougher than Santiago.