I have some USDT and USDC in my portfolio that I'd want to stake in a "De-Fi" dApp without worrying about it in a long time. There are liquidity pools in Uniswap with attractive stake rates, but there's also Compound.Finance with its lending services. Both of these platforms are built on the ETH blockchain, so gas fees would be astronomically high. I've read about some platforms being compatible with Polygon (MATIC), but I'd have yet to see if it's worth the shot (especially in terms of security/reliability).
Do you know the safest way to stake stablecoins without breaking the bank? Also, do you think it's worth it? Or should I consider other options? Any suggestions and/or recommendations would be greatly appreciated. Thanks in advance.

Use a website that has good trust if you want to stake in stablecoin in big amounts, Right now security is number one besides the return that the platform gives to us. You can stick with Uniswap for my recommendation and always be up to date on the news in case you miss the recent news about the platform for example the platform being bankrupt and giving limited time to withdraw the funds and the reward.