The teams are equal, I don't see any great prospects for Feyenoord, Roma can beat them, at least I think Real Sociedad is a stronger opponent than Feyenoord. And of the remaining clubs, Manchester United probably has the most chances to win the title, although Juventus and Sporting are also strong contenders. As for Bayer, I dont know how they can be assessed, they seem to be starting to get in good shape in recent games.
I think the strength of these two teams are relatively equal this season but the advantage is likely to be in Feyenoord favor as they host the first leg. If they can finish the first leg perfectly then their chances are relatively bigger to advance to the next round. but rome under coach mourinho they are getting stronger season after season. even this season roma seems to be a team that wants to target the Europa league championship. Their strength will be tested at home to Feyernoord in the first leg later.
juventus relatively got equally strong opponents, where Sporting became a very consistent team in the round of 16 when they were able to beat arsenal. This match is hard to guess and I think I will miss this match in my bet.