The match with Manchester City is a biggest one for Arsenal in rest of season as they are two direct competitors for the Premier League crown. Arteta and Arsenal don't have to win that match, they need to have a draw, prevent Manchester City to reduce 5 points gap and move on to collect points from other teams.
Don't think like that there are still 10 weeks to go, it's mean Manchester City can earn maximum of 30 points, it's enough to beat Arsenal at the top position. Arsenal always lost against Manchester City, so Arsenal still need to win regardless they're currently in a quite safe position and 8 points difference than Manchester City.
Maybe Arsenal have a slight advantage since Manchester City need to play at the other leagues, but it can put a pressure for Arsenal's players since Arteta will force them to win in this league, otherwise Arsenal will not get anything in this season.
The rest of the match is still long enough, at least the results obtained later for Arsenal and Manchester city will not always be the same. Even so, Manchester City does have an advantage with a small number of matches, this could be an opportunity for Pep Guardiola's squad to cut points from Arsenal. However, it looks like now the players will be preoccupied with the international break match and I hope that after the match is over, no players will be injured.