The most entertaining, well done and complete Play to Earn games developed so far didn't show any respect and consideration for the community of players, rather their only goal was to milk money from players, without caring about long term goals and survival of the game. They were MIR4 and Ni No Kuni. Bots and toxic players killed the environment. And that is so sad, because the games were really good and promising.
With some adjustments those games could be popular until nowadays, while working as side income for many players. If at some point in the future a studio comes with a similar idea, but propitiating a friendly environment for every players (not only the addicted, wealthy ones) I think it will be a huge success.
It would always be a non-stop race - devs versus botters. The botters always find a way. Look at runescape for example - even with all the ban waves, people still bot to this day.
Such game would need to be profitable as a business and have really good funding to be able to fight back botters.
I think the devs knows the permanen solutions to this bots problems, it is hard to stop bots activities but if the developers doesbn't want bots on their gaming websites, they can do it but I guess they also need it to manipulate the numbers of users, that is what some of them use to show their stats to other gaming competitors, they can announced and bost of having million user but if you check very well, the real users might not be up to 100k playing game and they will be the quick to cry that users are stealing rewards, they want users and bots but afraid of how the rewards are stolen by users.