I think 10 BTC and 100 ETH would set you up for good, so once that is reached, I would stop accumulating, what is your plan?
That's a fair amount to hold and if someone has that at the moment and keep on holding them, they can retire early to escape the 9-5 struggle. Let say you hold for a next 2 bull run and by then Bitcoin is now trading at $300k and Ethereum at $30k, that means you're 10 Bitcoin and 100 ETH will be worth $3m in Bitcoin and and $3m as well Ethereum.
That means you'll be having a combined total of $6m which is quite a lot, you're become a Millionaire and you can retire from your 9-5 to focus fully on investing and living like everyday is a vacation. Retiring means you'll stop working. Never think retiring means you'll stop investing as the moment you stop, you'll go broke like everyone else.