Didn't their last meeting take place several years ago, in 2020 to be precise? When compared to 2020 and this year especially after Ten Haag took over from Manchester United as coach there the difference is already very big and Manchester United are already in very good development at the moment so the previous H2H is unlikely to affect this match at all.
Sevilla must be very careful when dealing with Man United, the first or second leg will not give them a big advantage, because that was clearly seen when their opponent managed to hold Barcelona at the Nou Camp in the previous round, and finally beat Barca at Old Trafford, even though Barca is far more favored than United and also Barca is in relatively better condition than Sevilla, which is still outside the top 10 in the league until now. Man United are far superior to reach the semifinals and that could fail if their main player is injured or something else so he can't play for United, as long as all of Ten Haag's pillars are playing and fit then United will be difficult to contain by Sevilla.
To be fair they were good in 2020 as well and that I can understand. But this year Sevilla, even though they have somehow managed to come thus far, has been horrible and they are lucky to be here, they should have been out a few matches ago, and definitely a shock that they managed to be here. On the other hand, United looks like they could have been in UCL instead of here, they are pretty good and managed to beat Barcelona.
Look at Barcelona and sevilla positions in la liga and you would understand. This doesn't mean they will win for sure, United could still lose, as usual in football and especially in cup games anything could happen so we should be ready about that for sure.