When the draw brought Manchester United together, Sevilla's chances of qualifying for the semifinals might have been tightly closed. It must be admitted that the Red Devils are getting stronger this season under coach Erik Ten Hag. Not only that, the representative from England was also able to prove his prowess when he met Spanish representatives, namely Barcelona and Real Betis in the previous phase.
But if you view the results of the meeting of these two teams, MU must be extra vigilant. Noted, the two teams have met three times in European club competition. In the semifinals of the Europa League in 2020, MU lost 1-2. Then in 2018 in the last 16 of the Champions League, MU lost 1-2 in the first leg and drew 0-0 in the second leg. But that was when the condition of the Manchester United team was up and down, similar to the current condition of Sevilla.
The match will take place home and away, Sevilla's chances are still not closed and it depends on how the first leg goes. After all, Sevilla are very familiar with the European league and they have a different mentality when playing in the Europa League, so the match will be difficult to predict and Manchester United will also not easily get points in two matches.
But if you count the strength of the players and the consistency in their respective leagues, then I'm sure no one thinks Sevilla has a chance of beating Manchester United except for the Sevilla fans themselves. Head to head as you said is also different from the condition of the club at that time, so the potential for future matches will be much different.