It looks like the English Premier League is getting a tighter schedule including with Manchester United and it looks like, maybe this will affect the fitness and performance of the team a little to play against Sevilla later. So yes, with these factors, it is possible that Sevilla will be able to take advantage of the situation and conditions experienced by Manchester United.
If Sevilla can maximize this opportunity, then it is possible that we will get results that may be surprising. Because Manchester United is also still trying to be bigger in the Premier League to maintain its position in the top four, so player rotation is necessary but the results may not be as expected.
Sevilla, if you look at their history of performance in the Europa League has always been strong, so no matter in what shape and in what conditions now, the match will be difficult for both and it is hard to say who will win. There is not much time left before the match, it is too late to change anything in the lineup, but nevertheless, I think MU can win