Even though previously Sevilla were superior to Manchester United, this time Manchester United will turn things around. In the English league of course Manchester United are not so good for their game. But Bruno Fernandes, Marcus Rashford will make new history for Manchester United.
The meeting statistics can indeed be used as an indicator of how the match will go, but it will not be 100% accurate which means Manchester United have a chance to improve their meeting record. Now all in all I would say that Manchester United are better than Sevilla. If you are going to Sevilla to get through this round, then I am going to Manchester United to win this game.
I have always found the head to heads as a very weak type of understanding how teams would play. If they played recently then that could be an understanding, like I get Milan vs Napoli because they just recently played and then they are going to face each other in UCL as well, then you can maybe make a deduction out of that and even that is weak.
However, when it comes to teams that haven't played each other that much, and you have to go as further back as 2018, then it makes absolutely no sense at all. How many players are the same in both teams from the 2018 teams? Is the manager? Hell even owners change during that time for some teams. All in all I think head to head is a weak method to bet.