With a fairly busy schedule for Milan, it is likely that they will not appear with the main squad when they host Empoli. Maybe they will save the energy of their main players to better prepare for the match against Napoli in the champions league. But statistically even H2H Milan is actually still ahead by winning the game against Empoli. So in my opinion this will be an easy match for Milan, at least they have to win by scoring 2 goals to secure their position in the standings.
I think Milan actually has to field their best squad in this match. even though Empoli is not too strong, to prepare the best squad against Napoli, it is important to maintain readiness to finalize the strategy. they don't need to play the full game, then let the substitutes finish the game. Milan must also ensure victory, they are still fighting to finish in the top 4 with Roma and Inter.