Manchester United's problems aside from the away match for leg 2, they are also currently still a little vulnerable because many of their players are still unable to play due to injuries.
Bruno is no longer able to play due to card accumulation, while Rashford, Martinez and Varane are also doubtful now due to problems with his legs. This is really quite tough for Manchester United even though they are quite the favorites in this quarter final but with the current conditions this could be a reversal of fortunes for them and Sevilla.
Rashford and Varane should return soon, while Martinez has already been declared out for the remainder of the season. Without Rashford, they played Sevilla, and from my view, their performance was excellent up until the coach's careless substitution in the final minutes. They paid a heavy price for those substitution, and I have no doubt that they are already planning how to comfortably triumph over Sevilla in the return leg given that everyone sees that they are the superior team and should win this quarterfinal game. There current performance speaks well for them to win in the returning leg of the Europa League.