I don't expect Chelsea to make a comeback honestly. The players skills and concentrations are limited from a long time this season and I doubt Lampard's effect could be seen that early.
In the other hand, Real Madrid are the king of comebacks at Champions League by far, how could they let Chelsea pass

In my opinion Napoli vs Milan will be more interesting to follow since Napoli could win that game and even pass to the next stage before playing penalties tho.
I think so with Chelsea has difficult possibilities for come back on second leg because still on underperformance, last games in Primer League Chelsea defeated by Brighton Albion and not matter with playing home. Real Madrid has opportunity continue winning trend for second leg and I sure more than 75% chance for Real Madrid will qualify to the next round.
Chelsea still not in the winning trend last three matches, after losing from Real Madrid in Champion League they have loss from Wolves and last games Brighton Albion defeated Chelsea in domestic league. Crucial situation with Chelsea right now not only chance for qualifying to semifinal but also their position finish on top fourth standing in Primer League and get Champion League spot next season almost close.
Napoli has a good chance of winning. Osimen, a youthful and energetic player for Napoli, truly goes above and beyond to help his team win. I have faith in him to do what is necessary tonight, and if it ultimately results in a penalty, the game will evenly become a 50/50 game. As Chelsea's defense is a porous sack that can be breached at any time and Real Madrid is playing Chelsea for the second time following Madrid's victory, there is no doubt that Real Madrid will still win. I am confident of their success.