Both are skill based yet former is considered sheer gambling while later is not. Fantasy sports has become norm, while on the other hand if people come to know that you bet on sports you'll be met with eyebrow raise.
^ that's my opinion. What's yours? Do you consider both of them same or different?
Yes, they are very similar types of bets, but I still think that games based on real (not virtual) sports are much more predictable.
When betting on a European league football match, for example, there is much more information and predictions that can be used to base a betting scenario than when trying to get some information from a game like CS:GO or LoL
I've never bet on fantasy games, but I've followed it on some sites and in fact I see that this is a niche of bets that is growing more and more... my bets based on football sports games.