Manchester United has created problems for themselves allowing Sevilla to come back and draw that game, they played really bad in the second half of that match. The game is a 50/50 chance for both teams, Seville has always given Manchester united hard time in all the times they have played, but despite the injuring blow for the Manchester United team, they will definitely try everything possible to win this game. Manchester United perform better when they are not playing from home, is a win for Manchester United tonight.
Losing two goals and ending that match at home as a draw, in knock-out phase, it is terrible. Manchester United even got worse ending as they lost both Martinez and Varrane from that match with Sevilla.
They will have to play a second match in Seville with two alternative central defenders, Maguire and Lindeloff who can be their problems and weaknesses in the coming quarter final match. Sevilla won't play weakly at their home stadium and with fragile defense of Manchester United, we can see a win for Sevilla. I don't think the chance is 50/50 but it is bigger for Sevilla.
The absence of Rashford, Varane, and Martinez is giving me the feeling that Man United will not win today's game.
I want to bet on Sevilla but I don't want to waste my money.

. I lost money on both games yesterday so I decided I'll take a break today but it's looking like that break will be interrupted.
Manchester United will lose their best players for defense and attacking that is bad for them definitely.
Ten Hag is good to adjust the squad with players he has but Sevilla is a big challenge for them. At the knock-out phase, mistakes when appear will have very expensive cost and some times don't have chance to come back and fix it.