It's true the best moment to win in slots is bet with small amount money and hit a high multiplier, but the question is when we will hit it? 
I did hit a high multiplier but it's not that high compared with those gamblers, I think I haven't hit any high multiplier since the last year until now due to lack of money to gamble continuously and my busyness.
But I believe those gamblers have spent more than the huge wins they got
Whenever we are lucky we can hit that high multipliers we see from others bet slips although I am also among those players who have not been able to get into that levels but still trying with hope.I have seen some players getting huge win from small bets like of $1 or low being extremely lucky on first few bets only that they get really good profits.I did hit a high multiplier but it's not that high compared with those gamblers, I think I haven't hit any high multiplier since the last year until now due to lack of money to gamble continuously and my busyness.
But I believe those gamblers have spent more than the huge wins they got
So you need to be careful and those type of wins may not happen that much, it is a very rare thing. Instead look for like 100x or 500x returns and those are a bit more likely and it does happen, some slots have 500x and I have reached those a few times so far in my life, definitely great feeling.