The most popular - until BRC20 emerged - was Omni (2013) which seems to be continuosly updated and improved.
Hardly anybody uses Omni outside of Tether, which has largely migrated elsewhere. Some years back Tether forced a fork so they could perform rollbacks if need be and Omni went along with it. Since then, its been terribly unpopular.
https://tether.to/en/tether-critical-announcement/In terms of tx volume, Counterparty is by far the more popular tokenization protocol for BTC, and it will be once again after the Ordinals fad dies down.