The timezone is always a problem for someone as I remember the Korea-Japan world cup caused a lot of problems for those that wanted to watch the cup on the American continent, as you needed to watch the games at 3 AM, so as you may guess people were not really happy about it, still in a way that is one of the things that made that cup memorable as it was funny to hear the screams of joy and frustration at the place I lived of the people watching the games, as at that hour everything was very silent.
Difference culture will impact with new adopted by all player exactly with FIFA World Cup edition always in difference timezone, atmosphere and weather. Still remember last FIFA World Cup in Qatar due hot temperature with usually FIFA World Cup start in June and have to end year or December and make all players have adopted with hot weather in Qatar. But next FIFA World Cup seems help for European players because in United State, Mexico and Canada seems cool temperature and they will enjoy with the same weather in European contries.
For African and Asian must adapt to winter conditions with usually they play on hot weather, but its not problem because all player have understand and need adaption where every place games held on.