Inter Milan team will not be able to win against Manchester City if they play a defensive strategy only. Manchester City is one of the strongest attacking teams in the world. The city's midfield and attack are very strong. And so it will be risky for Inter Milan if they decide to play only a defensive strategy.
Inter will have zero chance if they open up to Man City and their only chance is to defend, hope that City wont have their day and possibly score on counterttack.
Even though City is a big favorute here, everyone should keep in mind that its only one game where everything is possible so I wouldnt write Inter all together.