Of course Roma is not safe because it is only 1 point at odds with Juventus. Losing or drawing will only make Roma fail to qualify for the Europa League considering that Juventus still hope to reach the Europa League next season. I think the last match will be very interesting because for sure it is a final for several teams.
Roma needs only a victory vs Spezia to get Europa League ticket or else wait for Juve to lose points. Ironically, Juventus and Roma have the same odds with 1.99 vs 3.9 for their opponents.
Atalanta have better odds too vs Monza so they might keep the other Europa League spot. Since Roma and Atalanta playing home and Juventus away, I am afraid the ranking will remain the same and Juve to move to Conference League next season.