According to some speculation, Inter will play Dzeko over Lukaku at the start.
Not sure if it is the correct choice, for sure he has more experience.
Inzaghi was making this decission the whole season, and it has worked, so lets see, Lukaku against tired defenders can be much more decisive, the main them its , are gonna be tired the defenders if Inter doesnt attack?
If Inter doesn't attack, then of course Manchester City's defensive line will logically not be too tired, but in this way Manchester City will have many ways to create attacks. So yes, I think it doesn't matter whether Dzeko or Lukaku will be played first because after all, the most important thing is whether Inter can break Manchester City's dominance in the match later. Because, if Inter can't do a lot of attacks too, then Inter's forward players will at least help the defense a lot too right.