Possibly. The way Casimero fight is different, more like a brawler, and his punch is not something a boxer could take when he ain't ready.
Perhaps Inoue has come to realize that Casimero is a highly dangerous fighter. This realization may have occurred when Casimero defeated Zolani Tete, who was considered a strong challenger for Inoue due to his height and reach advantage. However, Casimero found a way to effectively target Tete's body, which ultimately led to an early knockout.