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Yes, there are a number of things that you should pay attention to because a big team will lose balance if many of their core players leave in this summer's transfer window. Manchester city just made their history last season by winning the treble winner. So there are several steps that pep must anticipate to balance their strengths in the next season, where he must be able to persuade star players not to leave in this transfer market.
Indeed pep guardiola has some stock players but if some influential players in the depth of their squad leave in this transfer window then it is very likely that manchester city will also lose its best form next season. Therefore I think pep guardiola has to hold Walker and Silva to stay with them next season.
I think you have the correct assumption there, although I don't completely agree with you. Manchester City is a big team that is ready to bear all the consequences when they lose several important players. Gundogan and Mahrez have left, it is good to have another player fill the void in that position. Riyad Mahrez last season was good, but he has dropped a bit compared to the previous season. Riyad Mahrez only scored 5 goals in 30 appearances in the Premier League last season, but he created 10 assists to create goals for Manchester City.
Manchester City are not going to lose the balance just because a few players leave, but I agree it will be one of the issues the coach will need to adjust to. Pep Guardiola has some great midfielders, he has strong defenders too, so there shouldn't be too much trouble about his form next season.