Price goes up if more people think buyer was smarter, price goes down if vice versa.

"wow someone bought 200,000 bitcoins?.. why? maybe I should buy some too"
"wow someone sold 200,000 bitcoins?.. why? maybe I should sell some too"

or else generally more attention given to bitcoins, which is overall positive.

The worst would likely be if they were put for sale, and no one bought any, or they were sold at a deep discount.