If your output descriptors either include your derivation path, or are using the xpubs already derived from the relevant derivation paths, then yes.
Just be careful with hardened paths. You've said m/49/0/4, but I suspect you mean m/49'/0'/4'.
Thanks. So, the xpubs will point to the right addresses with or without the derivation paths?
What is the difference between m/49' and m/49? So far as I can see, the derivation paths for all my multisig wallets are hardened (i.e., m/49).