It is reported that Kevin De Bruyne will be absent for the next four months, if he has to undergo surgery. It is very possible that Man City will add new players in the remaining time of the transfer market, Lucas Paqueta is the talk for now. Reportedly Westham will not release his players at a low price, the price reaches 90 million euros.
There are several lists that are targeted by Man City to fill the void left by De Bruyne, that you mentioned has become a list that is widely reported but Man City is more on West Ham player Lucas Paqueta the possibility of the price can touching 100M because some offers have been rejected, because currently Man City have spent more including defender Gvardiol with 90M, so it is very natural if Lucas Paqueta supposes above 90M.
On the second matchday, the big match will probably be Tottenham against Manchester United, but even though it's a big match, I personally still believe Manchester United has a chance to win. Because after all, it looks like Tottenham still have to get used to their squad playing without Kane and also, several Tottenham players have suffered injuries that might not be able to play in the match against Manchester United later.
Man United's Odds are a bit below Spurs but they play away while Spurs definitely have confidence at home can be optimistic of winning, of course I favor Man United but I have to analyze again which Spurs players are injured whether it is important players or not.