If a coin introduces a completely new technology that enables a different function and is sustainable in the long term, does it have the potential to be a worthwhile investment?
Assess whether that new function is solving a problem that really exists. If it does, then you will not be "able" to get into buying it, because the demand from investors to grab some of it will be so high. If it does not, then its just another shitcoin in the cesspool. In most cases it will be the second one. Still if you are thinking that it might be good, observe it after it has launched and marketed for a couple of years before making the decision to buy some for your portfolio.
Usually this type of tech comes once a lifetime. Bitcoin has been one. We are yet to see another and we might never actually do so.
