What could happen in extremely rare cases is that a whale gets lucky and sends a casino into bankruptcy. However, I would not have come across such a case yet and you would probably actually need someone with a lot of Bitcoins ... and a lot of luck.
What happens is that the casino dealer will always win, indeed we will not find cases where someone is lucky to make the casino go bankrupt, on the other hand many people go bankrupt playing casino, but this is not the fault of the casino because the users cannot control themselves, because after all the casino not forcing anyone to earn big money on their site let alone pressuring their users to keep betting.
Everything returns to their respective users because from their decisions they can determine the desired gains and losses, so they can know when to play gambling and when to stop gambling, that's why we won't find someone who is always lucky to get successive wins to bankrupt the casino or bookie .