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Yeah there might be a surprise this week but I don't think Manchester United lose, the first reason they play at home so far Manchester United has been very difficult to beat at home and the worst thing that can happen is a draw. Another reason Manchester United really needs a win to increase their confidence in the upcoming match against Munich in the Champions League, apart from that 3 points can also increase their position in the standings I mean Manchester still wants to maintain the points difference.
What I am most looking forward to is the match between Man United vs Brighton, and Chelsea vs Bournemouth. Because these two clubs are the teams that are most active in recruiting players in the transfer market, the results do not yet appear significant for the clubs and that is why it is appropriate for later. Even though the Ten Hag squad is playing at home, and the chances of winning are quite big, it doesn't rule out the possibility of a surprise like what you said happening. It's true, the results of the match in the fifth week are very valuable for The Red Devils to play the next match in the UCL group stage.
Brighton has been phenomenal in the last two seasons, especially when looking at head to head meetings with United. In the last five meetings between the two, Brighton has been superior. With details of winning three times, drawing once and losing once, Ten Hag should be wary.